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Nervous impulses from the hypothalamus regulate the adrenal medulla. The adrenal cortex is regulated by a negative feedback loop involving the hypothalamus and the pituitary hormone adrenocorticotropic hormone (ACTH). The hypothalamus of the brain has an effect on both regions of the adrenal gland. The adrenal cortex is essential to life, but the adrenal medulla is not essential to life. The cortex and the medulla each produce and release their own type of hormones. The cortex and the medulla are derived from different embryonic tissues. The adrenal gland is composed of an outer cortex and an inner medulla. Because of where the adrenal gland is located, the adrenal gland is also called the suprarenal gland. The adrenal gland is found on the upper portion of each kidney.